The Coquihalla Highway is closed south of Kamloops following a serious accident.
Kamloops Fire Rescue crews were called to the scene just prior to 3 p.m.
Passenger vehicles are being detoured via Lac Le Jeune Road, while commercial vehicles are being sent to Highway 5A south. It is not known when the highway will reopen.
Argo Roads Thompson said traffic leaving Merritt is being detoured to Highway 5A, while southbound lanes remain open.
Kamloops Mounties are on scene investigating the crash which occurred in the eastbound lane of Highway 5 near the westbound exit for Highway 1. Police say both lanes into Kamloops are closed and the westbound road is down to one lane.