The province is reporting 427 new cases of COVID-19 and three further deaths due to the disease.
Numbers for the Interior Health region appeared to show promise on Tuesday, averaging just 23 cases per day over the long weekend, but on Wednesday the region had another 47 cases, on par with numbers in recent weeks.
All told, the province now has 4,130 active cases, with 232 in hospital and 63 of those in critical care.
In other health regions in the province, there have been 90 new cases in Vancouver Coastal Health, 236 in Fraser Health, 18 in Vancouver Island Health, 31 in Northern Health and five new cases in people who normally reside outside Canada.
To date, B.C. has had 74,710 cases of COVID-19, 69,167 of whom have recovered, while 1,317 have died.
Another 7,238 people are isolating and being monitored by public health due to exposure to confirmed COVID-19 cases.
On the vaccine front, the province has now delivered 176,015 doses of either the Pfizer or Moderna vaccines. Of those, 26,030 are second doses.
Deliveries of the Pfizer vaccine are expected to ramp up this week and in the coming weeks, following manufacturer delays that greatly slowed B.C.'s vaccine rollout.